Kelly Harkins (CEO, Claret Bioscience and Astrea Forensics): "Get more from less: The SRSLY sequencing preparation method"
In this talk, Dr. Rao (VP Partnerships and Clinical Affairs) talks about the application of ClaretBio's flagship library preparation method SRSLY in cfDNA fragmentomics. This field as emerged as the cutting edge of liquid biopsy based biomarker discover where fragmentation patterns - including cfDNA length and end-motifs can potentially be used in agnostic cancer diagnosis with low-depth DNA sequencing.
In this webinar, Jordan Cheng (UCLA, School of Dentistry) describes the development of an extraction methods to capture highly degraded cell-free DNA from urine and plasma. A new class of cfDNA called ultra-short cell-free DNA are retained by this method and provides improved insights to the origin of cfDNA.
In this first-talk of the webinar series, Ms. Adrienne Chang (Cornell University) talks about the challenges in metagenomic assays from cfDNA. She highlights utility of single-stranded library preparation such as SRSLY in retaining short fragments and improving overall quality of the data obtained from difficult to sequence DNA inputs